Give a Dog a Genome 2016

Glen Trio

Give a Dog a Genome banner

YES!

The UK's two Glen of Imaal Terrier breed clubs

The Glen of Imaal Terrier Enthusiasts and Fanciers Club (EFG) and The Glen of Imaal Terrier Association (GOITA)

are supporting the GIVE A DOG A GENOME (GDG) project


UPDATE - October 2017

The Animal Health Trust has published a further "progress timeline" for all the breeds participating in the GDG project. The Glen, on page 2, has reached "Sequencing data down-load and pre-analysis processing underway" on the timeline:

Breed Progress Report


UPDATE - July 2017

The Animal Health Trust has published a "progress timeline" for all the breeds participating in the GDG project. The Glen, on page 2, has reached "Suitable DNA identified, sent to commercial lab for sequencing" on the timeline:

Breed Progress Report


UPDATE from the GDG team - March 2017

1. Swab samples have been received from all three dogs.
2. They have not yet been sent to the sequencing lab as 2 of them only arrived after the last batch of samples were sent. [The GDG team is] gearing up to extract samples and send them off within the next few weeks. Assuming at least one of the three samples has sufficient quality DNA, it will be included in the next batch to be sent for sequencing.
3. The sequencing itself takes 6-8 weeks. Then the data we get back needs to be further processed, which takes 3-4 days. As the Glens are healthy controls, there won’t be any analysis results to report, but the sequencing data will be used as a control in all of our future studies, regardless of the breed or condition under investigation.


UPDATE - January 2017

The aim of GDG is to establish a genome bank to facilitate investigations of inherited disorders in all breeds of dog. A total of 86 dogs from 77 breeds will be whole genome sequenced in Give a Dog a Genome 1. To date, 28 samples from 25 breeds have been sent off for sequencing. More breeds are being invited to register their interest in Give a Dog a Genome 2, which is the second phase of this important project, anticipated to commence in 2018.

In May 2016, breed clubs were asked to complete a ‘Breed Health Information’ form, listing three health disorders of concern to their breed. Using data from three recent breed health surveys – the ongoing OFFA survey, the 2013 Finnish survey and the unpublished 2014 worldwide survey – the feedback form for Glens listed skin issues & allergies, foreleg issues and cancer as our main health concerns.

In December 2016, the Breed Club Health Coordinators were tasked with finding three healthy, older Glens, one of whom will be chosen as the Glen who will be whole genome sequenced. The identity of this Glen will be kept strictly confidential by the GDG team.

Once the GDG submissions have been received from the three Glens, the process of DNA sampling at the AHT will begin, and the candidate for whole genome sequencing chosen. The DNA of this Glen will then be sent to a commercial sequencing laboratory to be whole genome sequenced. As the volume of data for each individual sample is very large, it is impossible to predict how long the whole process will take but the GDG team will keep the Health Coordinators updated and notify them if anything relevant is found.

We would like to extend a big “Thank you” to the owners of the three Glens chosen, one of whom will provide a valuable contribution to an invaluable resource for future canine research.


What is GIVE A DOG A GENOME?

"The genome is the term given to all of the DNA that is needed to make a person, dog or other animal. The canine genome is a vast sequence of 2.4 billion bases, or letters, of DNA.

The DNA, which makes up the canine genome, codes for around 20 thousand proteins which are needed to make the cells, tissues and organs of the body. There are actually only four different letters that make up the DNA code; these are A, T, C and G. We can work out the order of DNA letters making up a genome using a technique known as DNA sequencing."


What are the objectives and benefits of GIVE A DOG A GENOME?

"GDG aims to use whole genome sequencing to better understand the changes in canine DNA that cause disease. The genome bank that is being generated will be a permanent resource to facilitate investigations of inherited disorders in all breeds of dog.

Whole genome sequencing will enhance our understanding of which changes in DNA sequence have an effect on dog health and which changes are benign or neutral. This information will have profound effects on our ability to identify mutations which cause inherited diseases in purebred dogs, and the rate at which we can develop new DNA tests as tools for breeders. Give a Dog a Genome will revolutionise canine genetics research and is therefore a hugely important project to the future of dog health."


How is GIVE A DOG A GENOME being funded?

  • The cost of whole genome sequencing is £2,000 for a single dog

  • The Kennel Club Charitable Trust has donated £75,000 to the project and 75 breed clubs have matched this amount

  • EFG and GOITA each donated £500


Which Glen will be whole genome sequenced?

  • The GDG team will liaise with the Health Coordinators to shortlist some possible candidate Glens

  • It is likely that the Glen chosen will be a healthy, older dog/bitch

  • The final decision as to which Glen will be whole genome sequenced will be made by the GDG team and the identity of their chosen Glen will not be disclosed


GDG was launched by the Kennel Club Genetics Centre at the Animal Health Trust in February 2016

Please click on the AHT logo for more information about GDG

AHT logo



If you require more information about the Give a Dog a Genome project, please do not hesitate to contact:

Miss Caitlin Forbes
EFG Health Coordinator
Email: caitlin.forbes@btinternet.com


CONFIDENTIALITY

We operate an informed consent database. All information sent to the EFG Health Coordinator remains confidential unless the owner specifically authorizes release of the information into the public domain. In the interests of monitoring breed health, Glen owners are encouraged to provide as much information about health issues as possible. Information entered into the Glen Health Database may be used for research and statistical reporting purposes, but reports will not disclose the identity of individual dogs.

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